As is often the case, this discovery occurred by accident. The researchers were studying a fruit fly version of ANCE, an enzyme that helps lower blood pressure. They noticed that Ance expression in the fly gut was patchy, and that the cells that contained it had strange characteristics. “We found that Ance labels some weird cells in the fruit fly gut,” says Yoo. “But it took a long time for us to figure out that these weird judi slot online jackpot terbesar cells were actually dying.” They found that the strange cells were dark, lacking nuclear membranes, mitochondria, and cytoskeletons, and sometimes even DNA and other cellular items that are needed for cells to stay alive.